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Electrospinning nanofibers of microbial polyhydroxyalkanoates for applications in medical tissue engineering
Author(s) -
Zhao XiaoHong,
Niu YiNuo,
Mi ChenHui,
Gong HaiLun,
Yang XinYu,
Cheng JiSiYu,
Zhou ZiQi,
Liu JiaXuan,
Peng XueLiang,
Wei DaiXu
Publication year - 2021
Publication title -
journal of polymer science
Language(s) - English
Resource type - Journals
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20210418
Subject(s) - electrospinning , polyhydroxyalkanoates , nanofiber , biocompatibility , materials science , tissue engineering , drug delivery , nanotechnology , polymer , biomedical engineering , composite material , medicine , biology , bacteria , metallurgy , genetics
Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio‐polymers synthesized by microorganism's materials. Due to excellent biocompatibility reasonable biodegradability and versatile material difference, PHAs are well medical biomaterials candidates for applications in tissue engineering and drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB and few uncommercial PHAs. Electrospinning nanofibers with the size of 10–10,000 nm can improve the mechanical properties and decrease the crystallinity of PHA, meanwhile simulate the structure and function of native extracellular matrix of cells. Hence, PHAs electrospinning nanofibers as engineered scaffolds have been widely used for tissue engineering scaffolds in cardiovascular, vascular, nerve, bone, cartilage and skin; also, as carriers for application in drug delivery system. In this review, we highlight the extraction and properties of medical PHAs from natural or engineered microorganism, and microstructure, current manufacturing techniques and medical applications of electrospinning nanofibers of PHAs. Moreover, the current challenges and prospects of PHAs electrospinning nanofibers are discussed rationally, providing an insight into developing vibrant fields of PHAs electrospinning nanofibers‐based biomedicine.