Premium
How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?
Author(s) -
Zhang Xinmo,
Contini Claudia,
Constantinou Anna P.,
Doutch James J.,
Georgiou Theoni K.
Publication year - 2021
Publication title -
journal of polymer science
Language(s) - English
Resource type - Journals
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20210371
Subject(s) - polymersome , copolymer , methacrylate , polymer chemistry , ethylene glycol , methyl methacrylate , polymerization , chemistry , materials science , chemical engineering , polymer , organic chemistry , amphiphile , engineering
Abstract Polymersomes are exciting self‐assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate‐based polymersomes is reported in this study. Five well‐defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2‐(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated.