How does the hydrophobic content of methacrylate  ABA  triblock copolymers affect polymersome formation? | Zendy

Zhang Xinmo | Zendy; Contini Claudia | Zendy; Constantinou Anna P. | Zendy; Doutch James J. | Zendy; Georgiou Theoni K. | Zendy

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How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?

Author(s) -

Zhang Xinmo,

Contini Claudia,

Constantinou Anna P.,

Doutch James J.,

Georgiou Theoni K.

Publication year - 2021

Publication title -

journal of polymer science

Language(s) - English

Resource type - Journals

eISSN - 2642-4169

pISSN - 2642-4150

DOI - 10.1002/pol.20210371

Subject(s) - polymersome , copolymer , methacrylate , polymer chemistry , ethylene glycol , methyl methacrylate , polymerization , chemistry , materials science , chemical engineering , polymer , organic chemistry , amphiphile , engineering

Polymersomes are exciting self‐assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate‐based polymersomes is reported in this study. Five well‐defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2‐(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated.

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