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Cover Image, Volume 59, Issue 10
Publication year - 2021
Publication title -
journal of polymer science
Language(s) - English
Resource type - Reports
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20210323
Subject(s) - cover (algebra) , transfection , cleavage (geology) , volume (thermodynamics) , computer science , chemistry , ethylene glycol , physics , materials science , biochemistry , organic chemistry , engineering , thermodynamics , mechanical engineering , fracture (geology) , gene , composite material
Oligo(ethylene imine)‐grafted peptides have emerged as powerful DNA and RNA transfectants, with a high transfection efficiency which exhibits an alternating trend (odd‐even effect) with respect to the graft length. The study from Costas S. Patrickios and colleagues on page 869 shows that totally abiotic backbones, polymethacrylate, in particular, grafted with oligo (ethylene imine)s, also present high transfection efficiencies with odd‐even patterns. The article further proves that unlike peptide backbones, polymethacrylate backbones are not main‐chain degradable, suggesting that the transfection properties are not influenced by backbone cleavage. (DOI: 10.1002/pol.20210101 )