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Mannosylated fluorescent cellulose‐based glycopolymers for stable uniform nanoparticles
Author(s) -
Wang Shuang,
Vana Philipp,
Zhang Kai
Publication year - 2021
Publication title -
journal of polymer science
Language(s) - English
Resource type - Journals
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20200714
Subject(s) - fluorescence , cellulose , amphiphile , rhodamine b , thiol , chemistry , rhodamine , aqueous solution , mannose , polymer chemistry , nanoparticle , combinatorial chemistry , organic chemistry , materials science , copolymer , polymer , nanotechnology , physics , quantum mechanics , photocatalysis , catalysis
In living organisms, carbohydrate‐protein interactions play key roles in physiological and pathological processes, which are amplified by the “glycol‐cluster effect.” In this work, we synthesized novel fluorescent cellulose derivatives bearing mannose moieties via thiol‐ene click reactions by sequentially conjugating hydrophilic mannose‐oxyethoxylpropane‐thiol (Mann‐SH) and fluorescent coumarin‐oxyhexyl‐thiol (Coum‐SH) and rhodamine B‐ethyl‐thiol (RhB‐SH) to cellulose undecenoate with terminal double bonds. The amphiphilic fluorescent cellulose derivatives were converted into nanoparticles (NPs) by dropping into low ionic strength solutions (<0.085 M). Obtained NPs have average sizes between 240 and 554 nm depending on the solution concentrations, exhibiting uniform size distributions (PDI values <0.12). These uniform NPs exhibited excellent dispersion stability even at elevated temperatures. The mannose moieties were accessible to 1,4‐benzenediboronic acid (BDBA) in NaOH aqueous solutions. Under irradiation with UV light of 320–400 nm, the fluorescence of NPs increased by the formation of open‐ring rhodamine spiroamide, which could be a promising candidate for biomedical application.