Premium
Synthesis of amphiphilic block copolymer using trimethylene carbonate bearing oligo(ethylene glycol) and investigation of thin film including cilostazol
Author(s) -
Nobuoka Hiroaki,
Nagasawa Masakazu,
Chanthaset Nalinthip,
Yoshida Hiroaki,
Haramiishi Yoshiaki,
Ajiro Hiroharu
Publication year - 2020
Publication title -
journal of polymer science
Language(s) - English
Resource type - Journals
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20200390
Subject(s) - copolymer , materials science , ethylene glycol , thin film , cilostazol , polymer chemistry , polymer , polycarbonate , chemical engineering , glass transition , substrate (aquarium) , composite material , chemistry , nanotechnology , biochemistry , oceanography , aspirin , geology , engineering
To prepare a thin film, the block copolymer poly(TMCM‐MOE3OM)‐ b ‐PTMC was prepared with different segment ratios of hydrophilic moiety. The glass transition temperature of poly(TMCM‐MOE3OM)‐ b ‐PTMC decreased as the content of TMCM‐MOE3OM increased as expected, and it was confirmed that the graft oligo(ethylene glycol) (OEG) affected intermolecular interaction. The polymers grafted with OEG showed a thermoresponsive property, which can be expected to be applied to materials triggered by temperature. A thin film was prepared by mixing block copolymer and cilostazol as a drug, and the distribution of cilostazol was observed. It was confirmed that cilostazol was uniformly distributed on the thin film and that local sustained release could be avoided at the time of elution. The eluting behavior of the thin film from the substrate was apparently affected on the segment ratio of the block copolymer. When the thin film was immersed in PBS, the eluting rate increased as the segment ratio of TMCM‐MOE3OM in the block copolymer increased. As a result, it is possible to control the eluting rate by changing the ratio of the hydrophilicity and the hydrophobicity of the block copolymer, contributing to the creation of a new coating material containing cilostazol.