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Target grafting of poly(2‐(dimethylamino)ethyl methacrylate) to biodegradable block copolymers
Author(s) -
Diaz Ivonne L.,
Sierra Cesar A.,
Jérôme Valérie,
Freitag Ruth,
Perez León D.
Publication year - 2020
Publication title -
journal of polymer science
Language(s) - English
Resource type - Journals
eISSN - 2642-4169
pISSN - 2642-4150
DOI - 10.1002/pol.20200204
Subject(s) - copolymer , cationic polymerization , polymer chemistry , atom transfer radical polymerization , ethylene glycol , polymerization , propargyl , methacrylate , click chemistry , azide , materials science , ring opening polymerization , grafting , reversible addition−fragmentation chain transfer polymerization , monomer , chemistry , radical polymerization , polymer , organic chemistry , catalysis
A series of copolymers composed of methoxy poly(ethylene glycol) and a hydrophobic block of poly(ɛ‐caprolactone‐ co ‐propargyl carbonate) grafted with poly(2‐[dimethylamino]ethyl methacrylate) was synthesized by combining ring opening polymerization, azide‐alkyne click reaction, and atom transfer radical polymerization (ATRP). Well‐defined copolymers with a target composition and a tailored structure were achieved via the grafting from approach by using a single catalytic system for both click reaction and ATRP. Kinetic studies demonstrated the controlled/living character of the employed polymerization methods. The thermal properties and self‐assembly in aqueous medium of the graft copolymers were dependent on their composition. The resulting polymeric materials showed low cytotoxicity toward L929 cells, demonstrating their potential for biomedical applications. This type of materials containing cationic side chains tethered to biocompatible and biodegradable segments could be the basis for promising candidates as drug and gene delivery systems.