Trained innate immunity and human adenovirus infection as a novel mechanism linked to the severe acute hepatitis of unknown origin in children during the COVID‐19 pandemic | Zendy

Du Lingyao | Zendy; Wang Jiayi | Zendy; Bai Lang | Zendy; Tang Hong | Zendy

Open Access

Trained innate immunity and human adenovirus infection as a novel mechanism linked to the severe acute hepatitis of unknown origin in children during the COVID‐19 pandemic

Author(s) -

Du Lingyao,

Wang Jiayi,

Bai Lang,

Tang Hong

Publication year - 2022

Publication title -

portal hypertension and cirrhosis

Language(s) - English

Resource type - Journals

eISSN - 2770-5846

pISSN - 2770-5838

DOI - 10.1002/poh2.20

Subject(s) - viremia , innate immune system , immunology , immunity , cytokine storm , inflammation , pathogenesis , immune system , pandemic , virology , biology , medicine , virus , covid-19 , disease , infectious disease (medical specialty) , pathology

Adenovirus (AdV) infection and immunity. Left panel: With trained immunity, inflammation is mild and confined to the gut. Right panel: Without trained immunity, AdV infection could lead to viremia, severe inflammation, and even a cytokine storm.

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