Open AccessTrained innate immunity and human adenovirus infection as a novel mechanism linked to the severe acute hepatitis of unknown origin in children during the COVID‐19 pandemic
Author(s) -
Du Lingyao,
Wang Jiayi,
Bai Lang,
Tang Hong
Publication year - 2022
Publication title -
portal hypertension and cirrhosis
Language(s) - English
Resource type - Journals
eISSN - 2770-5846
pISSN - 2770-5838
DOI - 10.1002/poh2.20
Subject(s) - viremia , innate immune system , immunology , immunity , cytokine storm , inflammation , pathogenesis , immune system , pandemic , virology , biology , medicine , virus , covid-19 , disease , infectious disease (medical specialty) , pathology
Adenovirus (AdV) infection and immunity. Left panel: With trained immunity, inflammation is mild and confined to the gut. Right panel: Without trained immunity, AdV infection could lead to viremia, severe inflammation, and even a cytokine storm.