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Mechanism and structure–reactivity correlation in the homogeneous, unimolecular elimination kinetics of 2‐substituted ethyl methylcarbonates in the gas phase
Author(s) -
Chuchani Gabriel,
Marquez Edgar,
Herize Armando,
Domínguez Rosa María,
Tosta María,
Brusco Doris
Publication year - 2003
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.665
Subject(s) - chemistry , steric effects , reactivity (psychology) , alkyl , substituent , reaction rate constant , hydrogen atom abstraction , kinetics , hydrogen , alkoxy group , oxygen , medicinal chemistry , stereochemistry , computational chemistry , organic chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics
The gas‐phase elimination kinetics of 2‐substituted ethyl methylcarbonates were determined in a static reaction system over the temperature range of 323–435°C and pressure range 28.5–242 Torr. The reactions are homogeneous, unimolecular and follow a first‐order rate law. The kinetic and thermodynamic parameters are reported. The 2‐substituents of the ethyl methylcarbonate (CH 3 OCOOCH 2 CH 2 Z, Z=substituent) give an approximate linear correlation when using the Taft–Topsom method, log( k Z / k H )=−(0.57±0.19)σ α +(1.34±0.49)σ R − ( r =0.9256; SD=0.16) at 400°C. This result implies the elimination process to be sensitive to steric factors, while the electronic effect is unimportant. However, the resonance factor has the greatest influence for a favorable abstraction of the β‐hydrogen of the C β —H bond by the oxygen carbonyl. Because ρ α is significant, a good correlation of the alkyl substituents of carbonates with Hancock's steric parameters was obtained: log( k R / k H ) versus E S C for CH 3 OCOOCH 2 CH 2 R at 400°C, R=alkyl, δ=−0.17 ( r =0.9993, SD=0.01). An approximate straight line was obtained on plotting these data with the reported Hancock's correlation of 2‐alkyl ethylacetates. This result leads to evidence for the β‐hydrogen abstraction by the oxygen carbonyl and not by the alkoxy oxygen at the opposite side of the carbonate. The carbonate decompostion is best described in terms of a concerted six‐membered cyclic transition state type of mechanism. Copyright © 2003 John Wiley & Sons, Ltd.