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Secondary α‐deuterium isotpe effect on the hydration of p ‐nitrobenzaldehyde
Author(s) -
Pires José Ricardo,
Stachissini Antonia Sonia,
Amaral Luciano Do
Publication year - 1994
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.610070405
Subject(s) - chemistry , deuterium , kinetic isotope effect , kinetic energy , heavy water , medicinal chemistry , quantum mechanics , physics
The secondary α‐deuterium isotpe effect on the equiliburium constant ( K D / K H ) for the hydration of p ‐nitrobenzaldehyde is 1·39 ± 0·05. The Kinetic secondary α‐deuterium isotope effect ( K D / K H ) for the addition of water to p ‐nitrobenzaldehyde is 1·18 ± 0·07. This result demonstrates that there is extensive carbon–oxygen bond formation in the transition state for addition of water to the carbonyl group of p ‐nitrobezaldehyde.