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Metal ion‐promoted hydrolysis of uridine 2′, 3′ ‐ cyclic monophosphate: Effect of metal chelates and uncomplexed aquo ions
Author(s) -
Kuusela Satu,
Lönnberg Harri
Publication year - 1992
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.610051205
Subject(s) - chemistry , denticity , phosphodiester bond , chelation , metal , hydrolysis , uridine , metal ions in aqueous solution , ligand (biochemistry) , nucleophile , inorganic chemistry , molecule , medicinal chemistry , organic chemistry , catalysis , rna , receptor , biochemistry , gene
The effect of a wide variety of metal ious and metal ion complexes on the hydrolysis of uridine 2′,3′‐cyclic monophosphate was studied over the pH range 4.5–8.0. The greatest rate accelerations observed were 10 7 –10 8 ‐fold. The kinetic data obtained are interpreted in terms of a mechanism involving arapid monodentate binding of the metal ion to the monoanionic phosphodiester and a subsequent intracomplex participation of the metal‐bound hydroxo ligand, either as a nucleophile attacking the tetracoordinated phosphorus or as a base facilitating an intermolecular attack of a water molecule. No effect on the product distribution between uridine 2′‐ and 3′‐monophosphates was observed.