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Survey of the DNA binding properties of natural and synthetic polyamino compounds
Author(s) -
Stewart Kent D.,
Gray Thomas A.
Publication year - 1992
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.610050807
Subject(s) - chemistry , polyamine , cationic polymerization , dna , amine gas treating , selectivity , stereochemistry , base pair , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Using a flourescence‐detected ethidium displacement assay, the calf thymus DNA complexation properties of 27 mono‐, di‐, tri‐, tetra‐ and hexacationic polyamines were determined. The DNA‐binding affinity of these polyamine compounds increased with increasing cationic charge on the polyamine. Although most of the compounds exhibited no base pair binding selectivity, two of the tricationic polyamines possessing additional neutral amine groups exhibited approximately tenfold GC binding selectivities.