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Correlation analysis between equilibria for addition of semicarbazide and hydroxylamine to several carbonyl compounds and their equilibria for addition of water
Author(s) -
Malpica A.,
Calzadilla M.
Publication year - 2003
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.594
Subject(s) - chemistry , semicarbazide , hydroxylamine , reactivity (psychology) , equilibrium constant , linear correlation , measure (data warehouse) , linear relationship , computational chemistry , medicinal chemistry , organic chemistry , medicine , statistics , alternative medicine , mathematics , pathology , database , computer science
Equilibrium constants for semicarbazide and hydroxylamine addition to several carbonyl compounds are reported and compared with those for addition of water. The results are correlated by the linear free relationship log K add = Sw + B , where w is a measure of the reactivity of a given compound to water addition, S is a measure of the sensitivity of the examined reactions compared with the model of hydration equilibrium constants and B is a constant for a given reaction series. Copyright © 2003 John Wiley & Sons, Ltd.