Premium
Consequences of proton transfer in guanidine
Author(s) -
Raczyńska Ewa D.,
Cyrański Michał K.,
Gutowski Maciej,
Rak Janusz,
Gal JeanFrançois,
Maria PierreCharles,
Darowska Małgorzata,
Duczmal Kinga
Publication year - 2003
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.578
Subject(s) - guanidine , chemistry , triethylamine , delocalized electron , solvation , proton , hydrochloride , gas phase , phase (matter) , organic chemistry , molecule , quantum mechanics , physics
Consequences of proton‐transfer reactions in guanidine in the solid state, solution and gas phase are discussed. Y‐delocalization, resonance and symmetry strongly influence the basicity of guanidine in the gas phase. These effects are, however, insufficient to explain the basicity of guanidine which in aqueous solution is stronger than that of trisubstituted alkylamines and proton sponge (DMAN). The intrinsic (gas‐phase) basicity of guanidine is close to that of triethylamine. The large difference between the basicities of amines and guanidine in solution is attributed to the important role played by effects such as polarizability and internal and external solvation. Copyright © 2003 John Wiley & Sons, Ltd.