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Density functional theory study of the Lewis acid‐catalyzed Diels–Alder reaction of nitroalkenes with vinyl ethers using aluminum derivatives
Author(s) -
Domingo Luis R.,
Asensio Amparo,
Arroyo Pau
Publication year - 2002
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.529
Subject(s) - chemistry , nitroalkene , lewis acids and bases , electrophile , cycloaddition , catalysis , vinyl ether , lewis acid catalysis , hsab theory , density functional theory , stereoselectivity , medicinal chemistry , organic chemistry , computational chemistry , enantioselective synthesis , polymer , copolymer
The inverse electron demand Diels–Alder reaction of nitroalkenes with vinyl ethers catalyzed by Lewis acids based on aluminum metal, AlMe 3 , Al(OMe) 3 and AlCl 3 was studied using density functional theory methods. A continuum model was selected to represent the effects of dichloromethane used as solvent. For this cycloaddition reaction two reactive channels corresponding to the endo and exo approach modes of the vinyl ether to the Lewis acid‐coordinated nitroalkene were studied. Coordination of the aluminum metal to an oxygen atom of the nitroalkene increases the electrophilicity of the heterodiene, decreasing the activation energy of the cycloaddition. The substitution effect on the aluminum metal with Me, OMe and Cl on the activation energy and the stereoselectivity is discussed. An analysis of the static electrophilicity on reactants allows an explanation of the behavior of these Lewis acid‐catalyzed cycloadditions. Copyright © 2002 John Wiley & Sons, Ltd.