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Influence of additive on the aggregation behavior of drug and cationic hydrotrope aniline hydrochloride mixtures: a physicochemical assessment
Author(s) -
Alghamdi Yousef G.,
Rub Malik Abdul,
Azum Naved,
Asiri Abdullah M.
Publication year - 2021
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.4120
Subject(s) - chemistry , mole fraction , micelle , critical micelle concentration , gibbs free energy , enthalpy , flory–huggins solution theory , cationic polymerization , aniline , aggregation number , urea , thermodynamics , organic chemistry , aqueous solution , physics , polymer
We investigated the influence of an additive (50 mmol kg –1 NaCl/300 mmol kg –1 urea [U]) on the aggregation of amphiphilic promethazine hydrochloride (PMH) drug and cationic hydrotrope–aniline hydrochloride (AnHCl) mixtures at various temperatures and ratios. The drug PMH is mostly used for the treatment of allergic symptoms. The obtained critical micelle concentration ( cmc ) values are well below the cmc id (ideal cmc ) value, which confirms interactions between components PMH and AnHCl in the solution mixture. The micellar mole fraction ( X 1 Rub , X 1 Rod , and X 1 id ) of the first component (AnHCl) was evaluated using different models, which suggested greater involvement of AnHCl in mixed micelles (as expected); besides, the obtained micellar mole fraction values increase with increase in the mole fraction ( α 1 ) of AnHCl. The interaction parameter ( β ) values obtained were negative, which confirms attractive interaction or synergism among the components. Activity coefficients ( f 1 Rub [AnHCl] and f 2 Rub [PMH]) values are always found below one confirming the nonideality as well as attractive interaction between the components. Different physicochemical parameters evaluated suggested attractive interaction between the components (PMH and AnHCl) in all studied solvents; however, in salt media, the interaction increases to some extent, whereas in urea media, it decreases to some extent. Diverse thermodynamic parameters (Gibbs free energy [Δ G m 0 ], enthalpy [Δ H m 0 ], and entropy [Δ S m 0 ]) of micellization were computed and discussed separately. The excess free energy ( ∆ G ex Rub ) values of all systems were negative, suggesting higher stability of formed mixed micelles as compared with singular‐component micelles.