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Creatinine recognition using designed synthetic receptors
Author(s) -
Jana Subrata,
Prajapati Sunita,
Suryavanshi Kishor Kumar,
Goswami Shyamaprosad,
Parida Rakesh,
Giri Santanab
Publication year - 2020
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.4066
Subject(s) - moiety , chemistry , creatinine , receptor , acetonitrile , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry
A series of neutral nonenzymatic receptors have been synthesized for the recognition of creatinine in a nondegrative way. The receptors contain different heterocyclic moieties for better interactions between host and guest. Among these, 1 , 4 , and 5 are fluorescent receptors for creatinine. From this study, it was found that the receptors 1 and 4 containing the naphthyridine moiety have higher binding affinity to the guest creatinine than receptors containing other heterocyclic moiety. Theoretical studies for the calculation of binding energy were carried out using discrete Fourier transform (DFT) for the hosts and their complexation with creatinine in both gas phase and acetonitrile medium.