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Mechanism for the reactions of sulfides with hypochlorous acid and N ‐chlorosulfon‐amides: Formation of solvated chlorosulfonium cation and λ 4 ‐sulfane intermediates
Author(s) -
Ruff Ferenc,
Szabó Dénes,
Rábai József,
Jalsovszky István,
Farkas Ödön
Publication year - 2019
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.4005
Subject(s) - chemistry , hypochlorous acid , chlorine , reactivity (psychology) , medicinal chemistry , sulfoxide , reaction mechanism , sulfide , photochemistry , inorganic chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
DFT computations have been performed to study the mechanism of the reactions of sulfides with hypochlorous acid and N ‐chlorosulfonamides. Sulfides can attack HOCl both at chlorine and oxygen atoms. The attack at chlorine results in the formation of chlorosulfonium cation (R 2 SCl + ) and OH − intermediates, which transform to sulfoxide product. The high free energy of activation (Δ G ‡ ), which is needed for the formation of ionic intermediates, is decreased considerably by solvation in protic solvents. Since the attack of sulfides at the oxygen atom of HOCl has low Δ G ‡ value, the chlorination of sulfides can compete with the attack at the oxygen atom only in protic solvents. Kinetic studies showed that the reactivity of species, formed from N ‐chlorosulfonamides in protic solvents, increases in the course: RSO 2 NCl − << RSO 2 NHCl < < RSO 2 NCl 2 . The chlorination of sulfides with RSO 2 NHCl or RSO 2 NCl 2 results in the formation of R 2 SCl + and RSO 2 NH − or RSO 2 NCl − intermediates, respectively, and the computed and experimentally derived Δ G ‡ data agree in these cases. Sulfilimine (R 2 S═NSO 2 R) and sulfoxide products are formed in the reaction of R 2 SCl + with RSO 2 NH − and water, respectively. Acyloxy‐chloro‐λ 4 ‐sulfane intermediates are produced in the reactions of N ‐chlorosulfonamides and sulfides, bearing 2‐carboxy‐phenyl group, without the intermediacy of chlorosulfonium cations. Explicit water molecules must also be included in computations for reactions proceeding with formation or destruction of ions, to get Δ G ‡ values, comparable with experimental data. Supporting information may be found in the online version of this paper.