Determination of p K a values of fluorocompounds in water using 19 F NMR

Brønsted acidities of 19 fluorocompounds in the p K a range from 3.5 to 10 have been measured in aqueous solution using an approach involving absolute and relative p K a measurements with 19 F NMR. 19 F NMR has not been frequently used for determining p K a values, but it has a number of advantages, especially when relative values are considered: accurate concentrations not needed, tolerant to impurities, several compounds can be measured simultaneously, several uncertainty sources cancel out.