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Use of dye complexation dynamics to determine α‐cyclodextrin host:guest stability constants
Author(s) -
Rodríguez María,
Silva Lara,
Parajó Mercedes,
RodríguezDafonte Pedro,
GarcíaRío Luis
Publication year - 2019
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3820
Subject(s) - chemistry , pulmonary surfactant , cyclodextrin , alkyl , host (biology) , equilibrium constant , inclusion compound , organic chemistry , ecology , biochemistry , biology
Dynamics of host:dye complexation have been used, as an alternative to displacement assays, for determination of additional host:guest stability constants. Requirement of this new methodology is host:guest complexation being much faster than host:dye in order to guaranty that host:guest system is in equilibrium at each time during dye inclusion into the host cavity. Methodology was tested by studying α‐CD:surfactant complexation using alkyltrimethylammonium surfactants with different alkyl chain length. Experimental results confirm the formation of 1:1 α‐CD:surfactant complexes with binding constants strongly dependent on the surfactant hydrophobicity.