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Mixtures of antidepressant amphiphilic drug imipramine hydrochloride and anionic surfactant: Micellar and thermodynamic investigation
Author(s) -
Khan Farah,
Rub Malik Abdul,
Azum Naved,
Asiri Abdullah M.
Publication year - 2018
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3812
Subject(s) - chemistry , pulmonary surfactant , amphiphile , aqueous solution , micelle , cationic polymerization , gibbs free energy , inorganic chemistry , organic chemistry , thermodynamics , polymer , biochemistry , physics , copolymer
Aggregation as well as thermodynamic behavior of amphiphilic imipramine hydrochloride (IMH) drug (antidepressant) and anionic surfactant (sodium dodecyl sulfate [NaDS] as well as sodium dodecylbenzenesulfonate [NaDBS]) mixtures as a function of solution composition in aqueous solutions have been evaluated by conductometry method at different temperatures. Surfactant (NaDS and NaDBS) employed in the current study is anionic in nature. Various theoretical models such as Clint, Rubingh, Motomura, and Rodenas were employed to gain information regarding the type of interaction between the components in the solution mixtures. The value of micellar mole fraction evaluated by different utilized models is found to be more for IMH‐NaDBS mixtures in comparison with IMH‐NaDS mixtures, signifying that participation of NaDBS is more in mixed micelles as compared with NaDS. Owing to the different charge of employed drug and surfactant, which sources high synergistic results in the mixed system comparative to the possessions of their pure compounds, means here anionic surfactants were elected in favor of the quantitation of cationic drug. The value of interaction parameters ( β ) was also evaluated by employing the Rubingh's model. The values of Gibbs free energy (∆ G 0 m ) for all systems attained to be negative in all studied systems showing that the systems are spontaneous in nature.