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Theoretical studies and antibacterial activity for Schiff base complexes
Author(s) -
Al Zoubi Wail,
AlHamdani Abbas Ali Salih,
Putu Widiantara I,
Hamoodah Rehab Ghalib,
Ko Young Gun
Publication year - 2017
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3707
Subject(s) - chemistry , schiff base , ligand (biochemistry) , metal , octahedron , bacillus subtilis , methylene , square pyramidal molecular geometry , stereochemistry , proton nmr , crystallography , nuclear chemistry , medicinal chemistry , bacteria , crystal structure , organic chemistry , biochemistry , receptor , biology , genetics
Abstract New ligand 4‐((2‐Hydroxy1‐naphthyl) methylene amino)‐1.5‐dimethyl‐2‐phenyl‐1H‐pyrazol‐3(2H)‐one (HL) was synthesized from the reaction of 2‐hydroxy‐1‐naphthaldehyde and 4‐aminophenaz one. A complexes of this ligand [VO(II)(HL)(SO 4 )], [Pt(IV)(L)Cl 3 ], [Re(V)(L)Cl 3 ]Cl, and [M(II)(L)Cl] (M═Pd(II), Ni(II), Cu(II)) were synthesized. The resulted compounds were characterized by IR, NMR ( 1 H and 13 C), mass spectrometry, element analysis, and UV‐Vis spectroscopy. Additionally, the spectroscopic studies revealed octahedral geometries for the Re(V), Pt(IV) complexes, and square pyramidal for VO(II), square planar for Pd(II) complex, and tetrahedral for the Ni(II) and Cu(II) complexes. Thermodynamic parameters (ΔE * , ΔH * , ΔS * , ΔG * , and K) were calculated using from the TGA curve Coats‐Red fern method. Therefore, hyper Chem‐8 program has been used to predict structural geometries of compounds in the gas phase. Finally, the synthesized Schiff base and its metal complexes were screened for their biological activity against bacterial species, 2 Gram‐positive bacteria ( Bacillus subtilis and Staphylococcus aureus ) and 2 Gram‐negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ).