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Does the 2,6‐didehydropyridinium cation exist?
Author(s) -
Jankiewicz Bartłomiej J.,
Vinueza Nelson R.,
Kirkpatrick Lindsey M.,
Gallardo Vanessa A.,
Li Guannan,
Nash John J.,
Kenttämaa Hilkka I.
Publication year - 2013
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3120
Subject(s) - chemistry , singlet state , reactivity (psychology) , protonation , photochemistry , triplet state , enediyne , ground state , excited state , fourier transform ion cyclotron resonance , reactive intermediate , singlet fission , computational chemistry , ion , molecule , stereochemistry , organic chemistry , atomic physics , medicine , physics , alternative medicine , pathology , catalysis
Reactive intermediates are key species involved in many chemical and biochemical processes. For example, carbon‐centered aromatic σ,σ‐biradicals formed in biological systems from naturally occurring enediyne antitumor antibiotics are responsible for the irreversible cleavage of double‐stranded DNA caused by these prodrugs. However, because of their high reactivity, it is very difficult or impossible to isolate and investigate these biradicals. The aromatic σ,σ‐biradical, 2,6‐didehydropyridine, has been speculated for many years to be formed in certain organic reactions; however, no definitive proof of its generation has been obtained. We report here the successful generation of protonated 2,6‐didehydropyridine and the examination of its chemical properties in the gas phase by using a Fourier transform ion cyclotron resonance mass spectrometer. The results suggest that a mixture of singlet (ground) state and triplet (excited) state 2,6‐didehydropyridinium cations was generated. The two different states show qualitatively different reactivity, with the triplet state showing greater Brønsted acidity than that of the singlet state. The triplet state also shows much greater radical reactivity than that of the singlet state, as expected because of the coupling of the nonbonding electrons in the singlet state. Copyright © 2013 John Wiley & Sons, Ltd.