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Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals
Author(s) -
Santos Pedro M. P.,
Vieira Abel J. S. C.
Publication year - 2013
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3104
Subject(s) - chemistry , cinnamic acid , decarboxylation , hydroxylation , radical , oxidative decarboxylation , oxidative phosphorylation , oxidative stress , benzene , medicinal chemistry , organic chemistry , biochemistry , enzyme , catalysis
Cinnamic acid and its derivatives react with hydroxyl radical (HO • ), in neutral medium, to give hydroxylation products, whether on the benzene ring or on the exocyclic chain, and decarboxylation products. The latter compounds are also obtained after oxidation of the same substrates by the SO 4 •− radical anion. Evidence was provided for the protecting effects afforded by cinnamic acid and hydroxylated derivatives against oxidative reaction mediated by HO • . By using adenine as a model compound, the results obtained suggest that the high protective effect is due to an antioxidising cascade process. Copyright © 2013 John Wiley & Sons, Ltd.