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Antioxidant behaviour of 2′‐hydroxy‐chalcones: a study of their electrochemical properties
Author(s) -
Serifi Olga,
Tsopelas Fotios,
Kypreou AnnaMaria,
OchsenkühnPetropoulou Maria,
Kefalas Panagiotis,
Detsi Anastasia
Publication year - 2013
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3071
Subject(s) - chemistry , chronoamperometry , platinum , glassy carbon , cyclic voltammetry , electrochemistry , electrode , chalcone , supporting electrolyte , inorganic chemistry , solvent , voltammetry , antioxidant , organic chemistry , catalysis
The electrochemical behaviour of 13 chalcone analogues was systematically studied by means of cyclic voltammetry and chronoamperometry at a glassy carbon (GC), gold and platinum working electrodes using two different supporting electrolyte/solvent combinations. It was found that chalcone analogues can be easily oxidized at both GC and gold working electrodes, but not at a platinum electrode. Principal component analysis was further employed to reveal similarities/dissimilarities between oxidation potentials, chronoamperometric signals and ability of the compounds to scavenge the reactive oxygen species H 2 O 2 . The study reveals the inverse proportional relationship between the scavenging ability of H 2 O 2 , expressed as IC 50 , and chronoamperometric signal at 800 mV using gold as working electrode. Copyright © 2012 John Wiley & Sons, Ltd.