Antioxidant behaviour of 2′‐hydroxy‐chalcones: a study of their electrochemical properties

The electrochemical behaviour of 13 chalcone analogues was systematically studied by means of cyclic voltammetry and chronoamperometry at a glassy carbon (GC), gold and platinum working electrodes using two different supporting electrolyte/solvent combinations. It was found that chalcone analogues can be easily oxidized at both GC and gold working electrodes, but not at a platinum electrode. Principal component analysis was further employed to reveal similarities/dissimilarities between oxidation potentials, chronoamperometric signals and ability of the compounds to scavenge the reactive oxygen species H 2 O 2 . The study reveals the inverse proportional relationship between the scavenging ability of H 2 O 2 , expressed as IC 50 , and chronoamperometric signal at 800 mV using gold as working electrode. Copyright © 2012 John Wiley & Sons, Ltd.