Premium
Thermal reaction of electron deficient 4‐oxo‐4 H ‐pyrazole 1,2‐dioxide with cycloheptatriene: the first examples of the formation of an endo ‐[4π + 6π]‐cycloadduct and an intramolecular 1,3‐dipolar reaction leading to a heterocage
Author(s) -
Yamaguchi Koki,
Eto Masashi,
Yoshitake Yasuyuki,
Harano Kazunobu
Publication year - 2013
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.3066
Subject(s) - chemistry , cycloheptatriene , cycloaddition , pyrazole , intramolecular force , selectivity , computational chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis
The reaction of 3,5‐bis(methoxycarbonyl)‐4‐oxo‐4 H ‐pyrazole 1,2‐dioxide (1a) with 1,3,5‐cycloheptatriene (2b) gave a mixture of the novel endo ‐[4 + 6]‐cycloadduct (4ab), anti‐exo ‐[4 + 2]‐cycloadduct (5ab), and the heterocage (6ab) derived from the intramolecular 1,3‐dipolar cycloaddition reaction of the syn‐endo ‐[4 + 2]‐cycloadduct. Analogous endo ‐[4 + 6] selectivity in 1,3‐dipolar cycloadditions has not been reported previously. The X‐ray analysis indicates that 6ab has a very long N sp3 –N s p3 bond distance of 1.617(4) Å. The cycloaddition behaviour is discussed on the basis of transition‐state structures optimized at the B3LYP/6‐31G(d) level of theory, from which predictions of the peri‐, regio‐, and stereoselectivities agreed well with the experimental results. Copyright © 2012 John Wiley & Sons, Ltd.