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The basicity of sulfonamides and carboxamides. Theoretical and experimental analysis and effect of fluorinated substituent
Author(s) -
Shainyan Bagrat. A.,
Chipaniina. N.,
Oznobikhina Larisa. P.
Publication year - 2012
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.2910
Subject(s) - chemistry , substituent , heteroatom , protonation , oxygen , benzamide , medicinal chemistry , nitrogen , proton affinity , organic chemistry , ring (chemistry) , ion
The basicity of a series of sulfonamides and carboxamides with respect to protonation and hydrogen‐bonded complex formation with phenol was investigated by calculations using the Becke three‐parameter hybrid functional combined with Lee–Yang–Parr correlation functional with the 6‐311G** and 6‐311++G** basis sets and by infrared spectroscopy. The effect of fluorinated substituent was studied for the two series. The proton affinity of nitrogen in sulfonamides is higher than oxygen, in contrast to carboxamides, which are protonated at oxygen. The phenyl group in benzenesulfonamide increases the basicity of both heteroatoms, but more strongly of the nitrogen, whereas in benzamide the effect on the two heteroatoms is about the same. The CF 3 group equally decreases the basicity of nitrogen and oxygen atoms in sulfonamides and carboxamides. The second fluorinated substituent decreases the basicity of oxygen in (CF 3 CO) 2 NH more strongly than of nitrogen. For sulfonamides, the same effect results in the reverse of the center of basicity from nitrogen in (MeSO 2 ) 2 NH to oxygen in (CF 3 SO 2 ) 2 NH. All studied carboxamides give H‐complexes via the carbonyl oxygen, whereas for sulfonamides two types of H‐complexes, with the OH···N and OH···O=S, were found theoretically, the latter being more stable. The exception is bisimide (CF 3 SO 2 ) 2 NH, for which only the OH···O=S complex is stable. Experimentally, only the oxygen‐bound complexes are observed. Analysis of the natural charges revealed an ‘abnormal’ increase of the electron density on the NH group by electron‐acceptor substituents in CF 3 SO 2 NHR, which was explained using the natural bond orbital analysis by loosening of the S–N bond because of orbital interactions with the σ* S−N orbital. Copyright © 2012 John Wiley & Sons, Ltd.