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Interaction of water‐soluble triphenylphosphines with β‐cyclodextrin: a quantum chemistry study
Author(s) -
Sayede Adlane,
Ferreira Michel,
Bricout Hervé,
Tilloy Sébastien,
Monflier Eric
Publication year - 2011
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.1833
Subject(s) - chemistry , van der waals force , phosphine , ring (chemistry) , molecule , cyclodextrin , triphenylphosphine , medicinal chemistry , stereochemistry , computational chemistry , organic chemistry , catalysis
The interaction of β‐cyclodextrin (β‐CD) with meta ‐trisulfonated triphenylphosphine derivatives bearing one or two methyl (or methoxy) groups on the aromatic rings has been investigated by PM3 calculations. The results show that phosphine molecules interact with β‐CD having either an unsubstituted sulfophenyl group or a substituted sulfophenyl group at the para and/or meta ‐position. The presence of one methyl or methoxy group in the ortho ‐position on each aromatic ring prevents the formation of an inclusion complex between meta ‐trisulfonated triphenylphosphine derivatives and β‐CD. The deeply included phosphines in the β‐CD cavity show significant van der Waals interactions with β‐CD. These interactions are at the origin of the high association constants between these molecules and β‐CD. Phosphines exhibiting small association constants interact with β‐CD by forming H‐bonds and weak (or null) van der Waals interactions. Copyright © 2011 John Wiley & Sons, Ltd.