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Catecholase and DNase activities of copper(II) complexes containing phenolate‐type ligands
Author(s) -
Peralta Rosely A.,
Bortoluzzi Adailton J.,
Szpoganicz Bruno,
Brandão Tiago A. S.,
Castellano Eduardo E.,
de Oliveira Mauricio Bof,
Severino Patrícia C.,
Terenzi Hernán,
Neves Ademir
Publication year - 2010
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.1779
Subject(s) - chemistry , potentiometric titration , copper , ligand (biochemistry) , aqueous solution , medicinal chemistry , hydrolysis , catalysis , titration , metal , redox , stereochemistry , cleavage (geology) , inorganic chemistry , organic chemistry , ion , receptor , biochemistry , geotechnical engineering , fracture (geology) , engineering
Three new homodinuclear complexes containing substituted phenolate‐type ligands based on the N 5 O 2 donor (2‐( N,N ‐Bis(2‐pyridylmethyl)aminomethyl)‐6‐( N′,N′ ‐(2‐hydroxybenzyl)(2‐pyridylmethyl))aminomethyl)‐4‐methylphenol (H 2 L‐H) were synthesized and characterized by X‐ray crystallography. Potentiometric titration studies in 70% ( v / v ) aqueous ethanol show that all three complexes exhibit a common {Cu II ( µ ‐phenoxo)( µ ‐OH)Cu II (OH)} core in solution. Kinetic studies on the oxidation reaction of 3,5‐di‐ tert ‐butylcatechol revealed that the catalytic activity of the metal complexes increases toward the ligand containing an electron‐donating group. In addition, these complexes also carried out DNA cleavage by hydrolytic and oxidative pathways. Copyright © 2010 John Wiley & Sons, Ltd.