Complexation of aminoglutethimide with native and modified cyclodextrins | Zendy

Nowakowski Michal | Zendy; Dlugosz Maciej | Zendy; Taraszewska Joanna | Zendy; Wojcik Jacek | Zendy

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Complexation of aminoglutethimide with native and modified cyclodextrins

Author(s) -

Nowakowski Michal,

Dlugosz Maciej,

Taraszewska Joanna,

Wojcik Jacek

Publication year - 2009

Publication title -

journal of physical organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.325

H-Index - 66

eISSN - 1099-1395

pISSN - 0894-3230

DOI - 10.1002/poc.1544

Subject(s) - chemistry , aminoglutethimide , molecule , cyclodextrin , stereochemistry , stability constants of complexes , organic chemistry , cancer , aqueous solution , breast cancer , aromatase , medicine

Complexations of R(+) and RS(+/−)aminoglutethimide (AGT), the drug used in a treatment of breast and prostate cancer with native and modified cyclodextrins ( α ‐CD, β ‐CD, γ ‐CD, 2,6‐di‐ O ‐methyl‐ β ‐CD (DM‐ β ‐CD), 2,3,6‐tri‐ O ‐methyl‐ β ‐CD (TM‐ β ‐CD) and carboxymethyl‐ β ‐CD (CM‐ β ‐CD)) were studied. The stability constants were determined with UV–Vis spectrophotometric method at pH 9.0. The NMR data obtained for TM‐ β ‐CD suggest that the complexation of AGT is possible from both sides of CD molecule. This was confirmed by molecular dynamic simulations. Copyright © 2009 John Wiley & Sons, Ltd.

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