Premium
Complexation of aminoglutethimide with native and modified cyclodextrins
Author(s) -
Nowakowski Michal,
Dlugosz Maciej,
Taraszewska Joanna,
Wojcik Jacek
Publication year - 2009
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.1544
Subject(s) - chemistry , aminoglutethimide , molecule , cyclodextrin , stereochemistry , stability constants of complexes , organic chemistry , cancer , aqueous solution , breast cancer , aromatase , medicine
Complexations of R(+) and RS(+/−)aminoglutethimide (AGT), the drug used in a treatment of breast and prostate cancer with native and modified cyclodextrins ( α ‐CD, β ‐CD, γ ‐CD, 2,6‐di‐ O ‐methyl‐ β ‐CD (DM‐ β ‐CD), 2,3,6‐tri‐ O ‐methyl‐ β ‐CD (TM‐ β ‐CD) and carboxymethyl‐ β ‐CD (CM‐ β ‐CD)) were studied. The stability constants were determined with UV–Vis spectrophotometric method at pH 9.0. The NMR data obtained for TM‐ β ‐CD suggest that the complexation of AGT is possible from both sides of CD molecule. This was confirmed by molecular dynamic simulations. Copyright © 2009 John Wiley & Sons, Ltd.