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Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
Author(s) -
Fernandez Luciana,
Calderón Marcelo,
Martinelli Marisa,
Strumia Miriam,
Cerecetto Hugo,
González Mercedes,
Silber Juana J.,
Santo Marisa
Publication year - 2008
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.1448
Subject(s) - chemistry , dendrimer , hydrazide , solubility , drug , combinatorial chemistry , liposome , stereochemistry , pharmacology , organic chemistry , biochemistry , medicine
In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′‐(benzo[1,2‐c] 1,2,5‐oxadiazol‐5(6)‐yl (N‐1‐oxide) methylidene]‐1‐methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug. Copyright © 2008 John Wiley & Sons, Ltd.