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Reactivity trends and stereospecificity in nucleophilic substitution reactions
Author(s) -
Uggerud Einar
Publication year - 2006
Publication title -
journal of physical organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 66
eISSN - 1099-1395
pISSN - 0894-3230
DOI - 10.1002/poc.1061
Subject(s) - chemistry , reactivity (psychology) , humility , relevance (law) , substitution (logic) , nucleophilic substitution , stereospecificity , substitution reaction , interpretation (philosophy) , epistemology , nucleophile , psychology , organic chemistry , philosophy , catalysis , theology , political science , law , medicine , linguistics , alternative medicine , pathology
To obtain the full overview of the mechanistic landscape of nucleophilic substitution reactions is a demanding pursuit. There are still many unexplored regions, and humility and carefulness should be exercised before drawing the final map. This review commentary emphasizes some recent findings of relevance to these questions. A critical account is given about commonly used concepts and practices for interpretation of reactivity trends. It is questioned whether the S N 2/S N 1 paradigm is fully appropriate for understanding the factors which govern the outcome of substitution reactions. Copyright © 2006 John Wiley & Sons, Ltd.