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Failure of elimination of amyloid‐β from the brain in Alzheimer's disease
Author(s) -
de Silva Prasanna,
Carare Roxana O,
Weller Roy O
Publication year - 2008
Publication title -
progress in neurology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 12
eISSN - 1931-227X
pISSN - 1367-7543
DOI - 10.1002/pnp.72
Subject(s) - disease , dementia , neuroscience , amyloid (mycology) , alzheimer's disease , medicine , amyloid β , psychology , pathology
Accumulation of amyloid‐β(Aβ) in the brain is a major cause of dementia in Alzheimer's disease.In this article,Dr de Silva,Dr Carare and ProfessorWeller review the mechanisms for the elimination of Aβ from the brain,the reasons why these mechanisms fail in Alzheimer's disease,and how understanding this failure may lead to new approaches to the treatment of Alzheimer's disease. Copyright © 2008 Wiley Interface Ltd