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Coexistence of seizure with Wilson's disease: a systematic review
Author(s) -
Ibrahim Wael
Publication year - 2020
Publication title -
progress in neurology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 12
eISSN - 1931-227X
pISSN - 1367-7543
DOI - 10.1002/pnp.559
Subject(s) - disease , medicine , population , epilepsy , wilson's disease , pediatrics , pathology , psychiatry , environmental health
Wilson's disease is a rare autosomal recessive disease with worldwide prevalence of about 30 individuals per million population. It is caused by mutation in the ATP7B gene, resulting in malfunctioning ATP7B protein with subsequent copper deposition in brain, kidneys, cornea and other organs. 1 Although early treatment of copper overload can be effective, long‐term de‐coppering therapy can result in epileptic seizures. Dr Ibrahim investigates the types, frequency and causes of seizures occurring concomitantly in patients with Wilson's disease.