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Front Cover: Protein Interaction Network Biology in Neuroscience
Author(s) -
Basu Avik,
Ash Peter EA,
Wolozin Benjamin,
Emili Andrew
Publication year - 2021
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.202170021
Subject(s) - proteomics , neuroscience , front cover , cover (algebra) , biology , computational biology , phenotype , protein function , protein–protein interaction , systems biology , disease , protein interaction networks , bioinformatics , medicine , microbiology and biotechnology , pathology , genetics , gene , mechanical engineering , engineering
DOI: 10.1002/pmic.201900311 In article number 1900311, Avik Basu et al. summarize the recent applications of functional proteomics and systems biology approaches to study protein‐protein interaction networks central to normal neuronal function, during neurodevelopment, and in neurodegenerative disorders. The cover image represents how protein‐protein interactions change in a normal (left) vis a vis a diseased brain (right). These alterations in protein interactions and functional modules can lead to disease phenotype and in cases significantly change the gross anatomy of the brain. In the background multiple methods to detect and understand these interactions are illustrated, which might help us to accomplish better disease management. The cover was designed by Yi Zheng.