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Front Cover: Distinct Metabolic Features of Pathogenic Escherichia coli and Shigella spp. Determined by Label‐Free Quantitative Proteomics
Author(s) -
Pettersen Veronika Kuchařová,
Steinsland Hans,
Wiker Harald G.
Publication year - 2021
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.202170011
Subject(s) - biology , escherichia coli , virulence , shigella , microbiology and biotechnology , pathogenic escherichia coli , proteome , proteomics , pathogenic bacteria , bacteria , phenotype , genetics , gene
DOI: 10.1002/pmic.202000072 E. coli are usually harmless enteric bacteria, yet, at the same time, common cause of urinary tract infection, septicemia, neonatal meningitis, food poisoning, and gastroenteritis. In article number 2000072, Pettersen et al. culture 23 E. coli and Shigella strains, including 11 clinical pathotypes and 2 non‐pathogenic strains, under the same condition and identify a considerable variation in their expressed proteomes. Metabolism‐, stress‐ and virulence‐associated proteins display the highest variations, and some E. coli pathotypes have more similar protein profiles even when the strains are not that genetically closely related. The results underline adaptation to the host environment as a critical trait of pathogenic E. coli and suggest that the degree of genetic relatedness may not necessarily be a good predictor of E. coli phenotypic characteristics.