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Front Cover: Evaluation of the Potential Risk of Advanced Peak Determination in Distorting Isobaric Labeling‐Based Single‐Shot Proteome Quantitation
Author(s) -
Wang Jinlong,
Zhang Yuanya,
Huang Xiahe,
Lu Dandan,
Wang Yingchun
Publication year - 2020
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.202070091
Subject(s) - single shot , proteome , isobaric process , chemistry , abundance (ecology) , sampling (signal processing) , quantitative proteomics , chromatography , analytical chemistry (journal) , front cover , mass spectrometry , proteomics , biology , physics , cover (algebra) , optics , biochemistry , mechanical engineering , thermodynamics , engineering , fishery , detector , gene
DOI: 10.1002/pmic.201900255 The advanced peak determination (APD) is an algorithm that facilitates sampling of low abundance peptide features intermingled with higher abundance ones within the same MS space for MS/MS fragmentation. Sampling such low abundance features increases the number of acquired MS/MS spectra while produces more chimeric spectra with heavy parent ion interference and low identification rate and could affect the accuracy of isobaric labeling‐based single‐shot proteome quantitation. More details can be found in article number 1900255 by Jinlong Wang et al.