Front Cover: Profiling the Protein Targets of Unmodified Bio‐Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry | Zendy

Hwang HuiYun | Zendy; Kim Tae Young | Zendy; Szász Marcell A. | Zendy; Dome Balazs | Zendy; Malm Johan | Zendy; MarkoVarga Gyorgy | Zendy; Kwon Ho Jeong | Zendy

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Front Cover: Profiling the Protein Targets of Unmodified Bio‐Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry

Author(s) -

Hwang HuiYun,

Kim Tae Young,

Szász Marcell A.,

Dome Balazs,

Malm Johan,

MarkoVarga Gyorgy,

Kwon Ho Jeong

Publication year - 2020

Publication title -

proteomics

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.26

H-Index - 167

eISSN - 1615-9861

pISSN - 1615-9853

DOI - 10.1002/pmic.202070061

Subject(s) - chemistry , front cover , tandem mass spectrometry , mass spectrometry , chromatography , drug discovery , proteomics , small molecule , tandem , liquid chromatography–mass spectrometry , affinity chromatography , target protein , drug , computational biology , biochemistry , cover (algebra) , enzyme , biology , pharmacology , mechanical engineering , materials science , engineering , composite material , gene

DOI: 10.1002/pmic.201900325 Identifying the target proteins of bioactive small molecules is a key step in understanding the mode‐of‐action of a drug and addressing the underlying mechanisms responsible for a particular phenotype. In article number 1900325 by Hui‐Yun Hwang et al., a robust method utilizing drug affinity responsive target stability (DARTS) and liquid chromatography/tandem mass spectrometry (LC‐MS/MS) plus other proteomic approaches is discussed as effective way to select the biologically relevant target proteins of bioactive small molecules.

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