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Front Cover: Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer
Author(s) -
Udupa Sunag,
Nguyen Stephanie,
Hoang Giang,
Nguyen Tu,
Quis Addison,
Pham Khoa,
Asaka Ryoichi,
Nguyen Kiet,
Zhang Cissy,
Elgogary Amira,
Jung Jin G.,
Xu Qingguo,
Fu Jie,
Thomas Ajit G.,
Tsukamoto Takashi,
Hanes Justin,
Slusher Barbara S.,
Cooper Arthur J. L.,
Le Anne
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201970191
Subject(s) - glutaminase , metabolic pathway , downregulation and upregulation , glutaminolysis , glutamine , enzyme , glutamate receptor , pancreatic cancer , metabolomics , front cover , biochemistry , chemistry , biology , microbiology and biotechnology , cancer , bioinformatics , glycolysis , gene , genetics , amino acid , cover (algebra) , mechanical engineering , receptor , engineering
DOI: 10.1002/pmic.201800451 Much like the classic arcade game “Whack‐a‐Mole”, cancer cells are able to upregulate a different metabolic pathway when one pathway is inhibited. Specifically, using metabolomics technologies with isotopic labelling, Sunag Udupa et al. demonstrate in article number 1800451 the production of glutamate from glutamine via the glutaminase II pathway when the glutaminase 1 pathway is inhibited. This metabolic adaptability of tumors justifies the need for targeting multiple metabolic pathways, aiming at both main and adaptive metabolic networks.