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Front Cover: Protective Cellular Mechanism of Estrogen Against Kidney Stone Formation: A Proteomics Approach and Functional Validation
Author(s) -
Peerapen Paleerath,
Thongboonkerd Visith
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201970171
Subject(s) - estrogen , kidney , kidney stones , estrogen receptor , calcium oxalate , in vitro , proteomics , chemistry , microbiology and biotechnology , intracellular , receptor , calcium , medicine , biology , biochemistry , cancer , breast cancer , gene
DOI: 10.1002/pmic.201900095 Estrogen has been thought to play a role in protecting kidney stone formation, but the cellular mechanism remained unclear. In article number 1900095, Peerapen and Thongboonkerd demonstrate that estrogen prevents kidney stone formation in vitro by reducing apical surface expression of two calcium oxalate crystal receptors, crystal‐binding capability, and intracellular ATP of renal tubular cells. Moreover, estrogen also enhances migration and tissue healing activity of renal tubular cells. Art designer: Supatcha Sassanarakkit.