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Front Cover: Phosphoproteome Profiling of Isogenic Cancer Cell‐Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Author(s) -
Weeraphan Churat,
Phongdara Amornrat,
Chaiyawat Parunya,
DiskulNaAyudthaya Penchatr,
Chokchaichamnankit Daranee,
Verathamjamras Chris,
Netsirisawan Pukkavadee,
Yingchutrakul Yodying,
Roytrakul Sittiruk,
Champattanachai Voraratt,
Svasti Jisnuson,
Srisomsap Chantragan
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201970101
Subject(s) - phosphorylation , exosome , biology , microvesicles , proteomics , protein phosphorylation , in vitro , front cover , microbiology and biotechnology , biochemistry , gene , microrna , protein kinase a , cover (algebra) , mechanical engineering , engineering
DOI: 10.1002/pmic.201800159 Protein phosphorylation is one of the most important and widespread molecular regulatory mechanism that controls nearly all aspects of cellular function. In article number 1800159, Churat Weeraphan et al. use two isogenic human CCA cells as an in vitro metastatic model to gain insights into the phosphorylation levels of exosomal proteins derived from highly invasive cells. Their finding provides evidence that cellular phosphorylation events may be dynamically reflected through exosomal phosphoproteins and well preserved in these nanoparticle‐lipid membranes as compared to soluble‐secreted proteins.