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Front Cover: Proteomic and Post‐Translational Modification Profiling of Exosome‐Mimetic Nanovesicles Compared to Exosomes
Author(s) -
Nasiri Kenari Amirmohammad,
Kastaniegaard Kenneth,
Greening David W.,
Shambrook Mitch,
Stensballe Allan,
Cheng Lesley,
Hill Andrew F.
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201970061
Subject(s) - microvesicles , proteome , proteomics , exosome , nanocarriers , endosome , computational biology , chemistry , biology , cell , bioinformatics , gene , biochemistry , microrna , drug delivery , organic chemistry
DOI: 10.1002/pmic.201800161 Proteomic profiling of mimetic‐nanovesicles (M‐NVs) generated from cells reveals a subset of proteins that are highly abundant in M‐NVs. M‐NVs are found to contain proteins associated with membrane and cytosolic components that largely represent the parental cell proteome, whereas the profile of exosomes highlights their endosomally derived origin. In article number 1800161 , Nasiri Kenari et al. demonstrate the potential advantage of M‐NVs as an alternative nanocarrier when spontaneous endosomal sorting of therapeutics is limited.