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Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge
Author(s) -
LangebeckJensen Kasper,
Shahar Or D.,
Schuman Erin M.,
Langer Julian D.,
Ryu Soojin
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201900028
Subject(s) - proteome , zebrafish , biology , environmental enrichment , adaptation (eye) , proteomics , flexibility (engineering) , neuroscience , environmental stress , computational biology , microbiology and biotechnology , bioinformatics , ecology , genetics , gene , statistics , mathematics
Abstract Adaptation to the environment during development influences the life‐long survival of an animal. While brain‐wide proteomic changes are expected to underlie such experience‐driven physiological and behavioral flexibility, a comprehensive overview of the nature and extent of the proteomic regulation following an environmental challenge during development is currently lacking. In this study, the brain proteome of larval zebrafish is identified and it is determined how it is altered by an exposure to a natural and physical environmental challenge, namely prolonged exposure to strong water currents. A comprehensive larval zebrafish brain proteome is presented here. Furthermore, 57 proteins that are regulated by the exposure to an environmental challenge are identified, which cover multiple functions including neuronal plasticity, the stress response, axonal growth and guidance, spatial learning, and energy metabolism. These represent candidate proteins that may play crucial roles for the adaption to an environmental challenge during development.