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Front Cover: The Adrenal Lipid Droplet is a New Site for Steroid Hormone Metabolism
Author(s) -
Yu Jinhai,
Zhang Linqiang,
Li Yunhai,
Zhu Xiaotong,
Xu Shimeng,
Zhou XiaoMing,
Wang Haizhen,
Zhang Hongchao,
Liang Bin,
Liu Pingsheng
Publication year - 2018
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201870201
Subject(s) - pregnenolone , steroid hormone , lipid metabolism , endocrinology , adrenal gland , biology , medicine , testosterone (patch) , hormone , dehydrogenase , enzyme , steroid , chemistry , biochemistry
DOI: 10.1002/pmic.201800136 In article number 1800136 , Yu et al. analyze the adrenal gland lipid droplet (LD) proteomes from human, macaque monkey, and rodent and reveal that steroidogenic enzymes are also present in abundance on LDs. The enzymes found include 3β‐hydroxysteroid dehydrogenase (HSD3B) and estradiol 17β‐dehydrogenase 11 (HSD17B11). Furthermore, the analyses demonstrate that HSD3B2 is localized on LDs. Further experiments confirm that isolated LDs from HeLa cells stably expressing HSD3B2 or from rat adrenal glands have the capacity to convert pregnenolone to progesterone. These data suggest that LDs may be important sites of steroid hormone metabolism.