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Front Cover: Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults
Author(s) -
Parsons Martin E. M.,
Szklanna Paulina B.,
Guerrero Jose A.,
Wynne Kieran,
Dervin Feidhlim,
O'Connell Karen,
Allen Seamus,
Egan Karl,
Bennett Cavan,
McGuigan Christopher,
Gheveart Cedric,
Ní Áinle Fionnuala,
Maguire Patricia B.
Publication year - 2018
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201870131
Subject(s) - proteome , platelet , proteomics , front cover , biology , population , computational biology , bioinformatics , genetics , immunology , medicine , gene , cover (algebra) , mechanical engineering , engineering , environmental health
DOI: 10.1002/pmic.201800219 Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the ‘platelet releasate’. In article number 1800219, Parsons et al. use label‐free quantitative (LFQ)‐proteomics analysis to provide a reproducible, quantifiable investigation of the platelet releasate from 32 healthy adults. Their results show that the platelet releasate has low‐population variance among healthy adults, rendering it a potentially useful platform for diagnostic fingerprinting of platelet‐related disease.