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Front Cover: Revealing the Inhibitory Effect of Ginseng on Mitochondrial Respiration through Synaptosomal Proteomics
Author(s) -
Kong Dezhi,
Tian Xiaolin,
Li Yunshan,
Zhang Saihang,
Cheng Yiru,
Huo Lifang,
Ma Huanhuan,
Yang Zuxiao,
Ren Leiming,
Zhang Mingquan,
Zhang Wei
Publication year - 2018
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201870091
Subject(s) - ginseng , proteomics , mitochondrion , oxidative phosphorylation , respiration , inhibitory postsynaptic potential , front cover , oxidative stress , biochemistry , chemistry , biology , pharmacology , microbiology and biotechnology , neuroscience , medicine , cover (algebra) , anatomy , gene , mechanical engineering , alternative medicine , pathology , engineering
DOI: 10.1002/pmic.201700354 Protective effects of ginseng on neurological disorders were reported by many literatures. In article number 1700354 , Kong et al. aim to identify global protein expression changes within cerebral cortical and hippocampal tissues when ginseng was administrated using large scale synaptosomal proteomics studies. The results indicate the majority of the altered proteins to be located in the mitochondria, directly or indirectly inhibiting mitochondrial oxidative respiration. Functional experiments confirm that ginseng's active ingredients—ginsenosides are able to inhibit oxidative phosphorylation in mitochondria.