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Front Cover: Organellar Omics – A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell
Author(s) -
Tharkeshwar Arun Kumar,
Gevaert Kris,
Annaert Wim
Publication year - 2018
Publication title -
proteomics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201870041
Subject(s) - proteome , proteomics , computational biology , chemistry , biology , cell , microvesicles , front cover , cover (algebra) , microbiology and biotechnology , nanotechnology , biochemistry , engineering , materials science , mechanical engineering , gene , microrna
DOI: 10.1002/pmic.201700113 The cover art represents the experimental workflow to analyse the biomolecular composition of purified plasma membranes and lysosomes. The methodology is based on the use of superparamagnetic iron oxide nanoparticles (SPIONs) with different functionalized groups. Aminolipid‐coated SPIONs are targeted to the cell surface while DMSA‐coated SPIONs are taken up by cells and chased to lysosomes. Magnetically isolated compartments are compatible for subsequent proteome and lipidome analysis. In their review, article number 1700113 , Tharkeshwar, Gevaert and Annaert go more deep into the different available strategies for subcellular omics analysis.