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Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response
Author(s) -
Petit Coralie,
Guillon Jordan,
Toutain Bertrand,
Boissard Alice,
Patsouris Anne,
Lelièvre Eric,
Guette Catherine,
Coqueret Olivier
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201800447
Subject(s) - senescence , proteomics , mechanism (biology) , biology , chemotherapy , cellular senescence , computational biology , cancer , cancer research , bioinformatics , microbiology and biotechnology , phenotype , genetics , gene , philosophy , epistemology
In primary cells, senescence induces a permanent proliferative arrest to prevent the propagation of malignant cells. However, the outcome of senescence is more complex in advanced cancer cells where senescent states are heterogeneous. Here, this heterogeneity is discussed and it is proposed that proteomic analysis should be used to identify specific signatures of cancer cells that use this pathway as an adaptive mechanism. Since senescent cells produce an inflammatory secretome, MRM approaches and quantification with internal standards might be particularly suited to follow the expression of the corresponding markers in body fluids. Used in combination with imaging medical technics, a better characterization of senescence heterogeneity should help to monitor the response to chemotherapy treatment.