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Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis
Author(s) -
Xing Peter Yuli,
Pettersson Sven,
Kundu Parag
Publication year - 2020
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201800419
Subject(s) - stem cell , biology , gut flora , crosstalk , niche , homeostasis , gastrointestinal tract , microbiome , microbiology and biotechnology , immunology , biochemistry , bioinformatics , physics , optics
Microorganisms that colonize the gastrointestinal tract, collectively known as the gut microbiota, are known to produce small molecules and metabolites that significantly contribute to host intestinal development, functions, and homeostasis. Emerging insights from microbiome research reveal that gut microbiota‐derived signals and molecules influence another key player maintaining intestinal homeostasis—the intestinal stem cell niche, which regulates epithelial self‐renewal. In this review, the literature on gut microbiota‐host crosstalk is surveyed, highlighting the effects of gut microbial metabolites on intestinal stem cells. The production of various classes of metabolites, their actions on intestinal stem cells are discussed and, finally, how the production and function of metabolites are modulated by aging and dietary intake is commented upon.