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Analyzing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer
Author(s) -
Megat Mohd Azlan PutriIntanHafizah,
Chin SiokFong,
Low Teck Yew,
Neoh Huimin,
Jamal Rahman
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201800176
Subject(s) - colorectal cancer , gut flora , biology , cancer , computational biology , immunology , genetics
Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host–microorganism relationship or they may even serve as useful biomarkers for CRC. However, secretomic studies of gut microbiome of CRC patients, until now, are scarcely performed. In this review article, the focus is on the roles of gut microbiome in CRC, the current findings on CRC secretome are highlighted, and the emerging challenges and strategies to drive forward this area of research are addressed.