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In‐Cell NMR Spectroscopy of Intrinsically Disordered Proteins
Author(s) -
Sciolino Nicholas,
Burz David S.,
Shekhtman Alexander
Publication year - 2019
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/pmic.201800055
Subject(s) - intrinsically disordered proteins , nucleoporin , nuclear magnetic resonance spectroscopy , nuclear pore , microbiology and biotechnology , biology , two dimensional nuclear magnetic resonance spectroscopy , chemistry , biophysics , cytoplasm , biochemistry , nuclear transport , cell nucleus , organic chemistry , stereochemistry
This review summarizes the results of in‐cell Nuclear Magnetic Resonance, NMR, spectroscopic investigations of the eukaryotic and prokaryotic intrinsically disordered proteins, IDPs: α‐synuclein, prokaryotic ubiquitin‐like protein, Pup, tubulin‐related neuronal protein, Tau, phenylalanyl‐glycyl‐repeat‐rich nucleoporins, FG Nups, and the negative regulator of flagellin synthesis, FlgM. The results show that the cellular behavior of IDPs may differ significantly from that observed in the test tube.